Parvovirus infection in a child with acute lymphoblastic leukemia.

نویسندگان

  • M Alberti
  • G M Fiori
  • M A Sanna
چکیده

A6-year-old boy on maintenance treatment for acute lymphoblastic leukemia (according to mid-risk Protocol for ALL A.I.E.O.P. 9502) came to our observation because of anemia (Hb = 7 g/dL) and mild thrombocytopenia of no apparent etiology. A May-Grünwald-Giemsa stained blood smear revealed the presence of neutrophilia and rare immunocytes. Bone marrow smears showed maturation arrest of erythroid series, degenerated giant proerythroblasts with vacuolated cytoplasm and bare nuclei (Figures 1 and 2). This picture was suggestive of parvovirus B19 infection, which was confirmed by PCR analysis.1 The patient was treated with a single 12 hour infusion of immunoglobulin at the dose of 800 mg/kg, which led to complete normalization of the blood picture.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pneumothorax and Acute Kidney Injury in the Early Phase of Acute Lymphoblastic Leukemia Induction Therapy due to Aspergillus Fumigatus and Pneumocystis Jirovecii Co-Infection: A Case Report

Leukemia is the most common malignancy in children which leads to immunosuppression and predisposes patients to opportunistic infections. We report a 12-year-old girl with acute lymphoblastic leukemia (ALL) who developed simultaneous infection with pneumocystis Jirovecii pneumonia and aspergillosis in the induction phase of chemotherapy. The patient developed pulmonary cavitation and pneumothor...

متن کامل

Central Hypothyroidism: A Rare Complication in a Child Undergoing Chemotherapy for Acute Lymphoblastic Leukemia

Abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. We report an 11 years old girl who developed central hypothyroidism and ACTH deficiency during the chemotherapy for CNS relapse of acute lymphoblastic leukemia before receiving radiotherapy. Keywords: Thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leu...

متن کامل

Evaluation of Changes in NFKB Gene Expression Following Epstein-Barr Virus and its Participation in the Half-Life of Patients With Acute Epstein-Barr Positive Lymphoblastic Leukemia

Aim: Leukemia targets are one of the most common childhood malignancies. Epstein-Barr virus is a tumorigenic virus of the herpes family of viruses and causes primary infection in young children. The aim of this study was to evaluate the increase in NFKB expression following EBV virus and its contribution to the half-life of EBV-positive acute lymphoblastic leukemia patients. Materials and Meth...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Haematologica

دوره 84 1  شماره 

صفحات  -

تاریخ انتشار 1999